Dr. Birendranath Banerjee
Associate Professor
Ph. D. SVYASA - MANIPAL Bangalore 2007
M. Sc. Sri Ramachandra Medical University Chennai


Email : bnbanerjee@kiitbiotech.ac.in

Postdoctoral Experience

  1. 2005-2008 Department of Physiology Yong Loo lin School of Medicine National University of Singapore(NUS).
  2. 2007 September- 2007 November( Visiting Scientist) National institute of radiation Sciences (NIRS)Chiba Japan
  3. January 2013- June 2013 Department of Cellular and Molecular Biology, Baylor College of Medicine Houston USA.

Research Interest

Group leader: Molecular Stress and Stem cell Biology Group (MSSB)
Area of specialization is Stress induced genome stability Network and its role in Disease manifestation. The major goal of the group is to understand and elucidate mechanistic link between subtle changes in the Human genome which is functionally relevant to life style induced disorder including Cancer, Diabetes and Cardiovascular ailments. The focus is to understand the Biology of telomere dysfunction and its regulatory role in multiple pathways of stem cell differentiation and dedifferentiation.
Current projects: -

  1. Wnt b catenin and its role in therapeutic resistance and recurrence in Head and neck cancer cases of Odisha( Funded by DBT)
  2. Chronic infection spectrum and the role of TLR induced Genome instability in patients affected by long term infection.( Funded by DBT Twinning grant)
  3. Radiation induced DNA damage and therapeutic resistance mechanisms in Radio-tolerant population of Cancer stem cells. (Funded by Board of Research in Nuclear Sciences BRNS, DAE, Govt of India)

Besides basic Science research and academics he is also an entrepreneur and founded a start up venture named inDNA life sciences Pvt Ltd currently incubating in KIIT -TBI Bhubaneswar

Awards/Honours

  1. Best Essay awarded by the Ministry of Human Resources Govt of India as part of the 50th year of Indian Independence in 1996 and taken for India tour by the Ministry of Human Resources Govt of India
  2. Best outgoing Student by the Department of Microbiology AMC College 1999.
  3. Awarded Research fellowship by Atomic Energy Regulatory Board BARC Govt of India on a project titled Study of Telomeric Damage patterns of cancer patients before and after Radiotherapy.
  4. Young Scientist of The Year 2003 conferred by the Indian Society of Human genetics at its XXIII Annual Conference of The Indian Society of Human Genetics held at University of Jammu in February2003
  5. Best Poster Award awarded for the paper titled “Cytogenetics of Forty Glioma Samples a comparative study” Divya AT Sridevi Hegde A.S Hegde, B.N.Banerjee, Cini Samuel, Dept of Medical genetics Manipal Hospital Bangalore India Conferred by Indian Society of Human genetics at its XXIV Annual Conference at The Indian Society of Human Genetics (ISHG) held at NIMAHANS Bangalore India February 2004.
  6. International travel award by Department of Science and technology Govt of India to attend Telomeres and Telomerase May 3rd -7th 2011 held at Cold Spring harbor laboratory New York USA.
  7. DBT CREST award by Department of Biotechnology Ministry of Science and Technology Govt of India to visit Baylor college of Medicine, Houston Texas USA.

Selected Publications

Full List
  1. Souvick Roy, Abhik Chakraborty, Chinmoy Ghosh, Birendranath Banerjee* Systematic Analysis of Integrated Gene Functional Network of Four Chronic Stress-related Lifestyle Disorders  Genome Integrity ( Accepted March 2015) *Correspondence
  2. Padhi S., Saha A., Kar M., Ghosh C., Adhya A., Baisakh M., Mohapatra N., Venkatesan S., Hande M.P. and Banerjee BN*. (2015). Clinico-Pathological Correlation of β-Catenin and Telomere Dysfunction in Head and Neck Squamous Cell Carcinoma Patients. Journal of Cancer; Vol. 6, pp 192-202. *Correspondence
  3. Saha A., Padhi S.S., Roy S. and Banerjee BN*. (2014). Method of detecting new cancer stem cell-like enrichment in Development Front Assay (DFA). Journal of Stem Cells; 9(4): 235-242. *Correspondence
  4. Saha A., Padhi S.S., Roy S. and Banerjee BN*. (2014). HCT116 colonospheres shows elevated expression of hTERT and β-catenin protein- A short report. Journal of Stem Cells; 9(4): 243-251. *Correspondence
  5. Padhi SS, Kar M, Saha A, Baisakh MR, Mohapatra N, Banerjee BN*. Rapid recurrence and poor prognosis with altered levels of β-catenin in 3 cases of head and neck Squamous cell carcinoma patients. Head Neck Oncol 2014 Aug 18; 6(4):39. *Correspondence
  1. Wnt b catenin and its role in therapeutic resistance and recurrence in Head and neck cancer cases of Odisha
    Project Goal: In this work we are trying to understand the burden of minimum residual disease and its correlation with cancer stem cells and recurrence in especially in young population of Oral cancer patients.   (Funded by Department of Biotechnology Govt of India.)
  2. Chronic infection spectrum and the role of TLR induced Genome instability in patients affected by long term infection.
    Project Goal: This is a collaborative work with Dr. Surajit Bhattachrya from Tripura Central University where we are trying to understand the mechanistic link between chronicity of infection and genome instability and telomere Dysfunction. (Funded by Department of Biotechnology Govt of India.)
  3. Radiation induced DNA damage and therapeutic resistance mechanisms in Radio-tolerant population of Cancer stem cells. ( Funded by Board of Research in Nuclear Sciences BRNS, DAE, Govt of India)
    Project Goal:  Cancer stem cells are known to be resistant to Chemotherapy and Radiation. Post radiation minimum residual disease is caused by the resistant properties of cancer stem cells. We are trying to understand the DNA damage response and pathways responsible for the therapeutic resistance phenotype.

Prof. Sridevi Hegde
Head Dept of Medical Genetics Manipal Hospital Bangalore)

Prof. Tapas K Kundu
Transcription and disease laboratory,(Jawaharlal Nehru Center for Advanced Scientific Research(JNCASR, Bangalore)

Prof. Jeffrey M. Rosen
(Department of cellular and Molecular Biology, Baylor College of Medicine, Houston Texas, United States of America)

Prof. M. Prakash Hande
Genome stability laboratory, Department of Physiology( National University of Singapore)

Dr. Surajit Bhattacharya
Department of Molecular biology and Bioinformatics
Tripura central university Tripura Agaratala.

Dr. Madhabananda Kar
madhabananda@gmail.com

Swati Shree Padhi
swatishree18@gmail.com

Arka Saha
arka.saha0607@yahoo.in

Chinmoy Ghosh
chinmoy.biotech@gmail.com

Shomereeta Roy
shomereeta@gmail.com

Souvick Roy
Junior Research Fellow
souvickroy25@yahoo.com

Abhik Chakraborty
Junior Research Fellow
abhikbio523@gmail.com

2013-14

  1. Souvick Roy, Abhik Chakraborty, Chinmoy Ghosh, Birendranath Banerjee* Systematic Analysis of Integrated Gene Functional Network of Four Chronic Stress-related Lifestyle Disorders  Genome Integrity ( Accepted March 2015) *Correspondence
  2. Padhi S., Saha A., Kar M., Ghosh C., Adhya A., Baisakh M., Mohapatra N., Venkatesan S., Hande M.P. and Banerjee BN*. (2015). Clinico-Pathological Correlation of β-Catenin and Telomere Dysfunction in Head and Neck Squamous Cell Carcinoma Patients. Journal of Cancer; Vol. 6, pp 192-202. *Correspondence
  3. Saha A., Padhi S.S., Roy S. and Banerjee BN*. (2014). Method of detecting new cancer stem cell-like enrichment in Development Front Assay (DFA). Journal of Stem Cells; 9(4): 235-242. *Correspondence
  4. Saha A., Padhi S.S., Roy S. and Banerjee BN*. (2014). HCT116 colonospheres shows elevated expression of hTERT and β-catenin protein- A short report. Journal of Stem Cells; 9(4): 243-251. *Correspondence
  5. Padhi SS, Kar M, Saha A, Baisakh MR, Mohapatra N, Banerjee BN*. Rapid recurrence and poor prognosis with altered levels of β-catenin in 3 cases of head and neck Squamous cell carcinoma patients. Head Neck Oncol 2014 Aug 18; 6(4):39. *Correspondence
  6. Banerjee B*, Hande MP. Age-independent telomere shortening and ion-channel defects in SCD.Nature Review Cardiology. 2013 Jun; 10(6):362. doi: 10.1038/nrcardio.2013.30-c1. Epub 2013 Apr 30. *Correspondence
  7. Soumitra Mohanty, Prajna Jena, Ranjit Mehta, Rashmirekha Pati, Birendranath Banerjee, S Patil, Avinash Sonawane. Cationic antimicrobial peptides and biogenic silver nanoparticles kill mycobacteria without eliciting DNA damage and cytotoxicity in mouse macrophages. Antimicrob Agents Chemother. 2013 Aug; 57(8):3688-98. doi: 10.1128/AAC.02475-12. Epub 2013 May 20
  8. A. Ram, Birendranath Banerjee, V.S. Hosakote, R.M. Rao, R Nagarathna. Comparison of lymphocyte apoptotic index and qualitative DNA damage in yoga practitioners and breast cancer patients: A pilot study. Int J Yoga. 2013 Jan;6(1):20-5. doi: 10.4103/0973-6131.105938.

2010-2012

  1. Bhattacharjee RN, Banerjee B, Akira S, Hande MP, 2010 Telomere-mediated chromosomal instability triggers TLR4 induced inflammation and death in mice. PLoS ONE.2010
  2. Hiroyuki Niida, Kazuhiro Murata, Midori Shimada, Kumiko OgawaKumiko OhtaKyoko Suzuki3, Hidetsugu Fujigaki, Aik Kia Khaw, Birendranath Banerjee, M. Prakash Hande, and Makoto Nakanishi ( July 2010) Cooperative functions of Chk1 and Chk2 reduce tumor susceptibility in vivo EMBO .J
  3. Banerjee B, Peiris DN, Koo SH, Chui P, Lee EJD, Hande MP† 2009 Genomic imbalances in key ion channel genes and telomere shortening in sudden cardiac death victims Cytogenetic and Genome Research ( Accepted In press) IF 2.402 http://dx.doi.org/19188705

2008-2010

  1. Poonepalli A, Banerjee B, Ramanarayan K, Palanisamy N, Putti TC, Hande MP 2008 Telomere mediated genomic instability correlates with the clinico-pathological parameters of breast cancer Genes Chromosomes and Cancer 47(12): 1098-1109.  IF 4.532 http://www.ncbi.nlm.nih.gov/pubmed/18720522
  2. Vinoth KJ, Heng BC, Poonepalli A, Banerjee B, Balakrishnan L, Lu K, Hande MP, Cao T 2008 Human embryonic stem cells may display higher resistance to genotoxic stress compared to primary explanted somatic cells Stem Cells and Development 17 (3): 599-608. IF3.22 http://www.ncbi.nlm.nih.gov/pubmed/18498216
  3. Newman JPA, Banerjee B, Fang W, Poonepalli A, Balakrishnan L, Low GKM, Bhattacharjee RN, Akira S, Jayapal M, Melendez AJ, Lee HW, Hande MP 2008 Short dysfunctional telomeres impair the repair of arsenite-induced oxidative damage in mouse cells. Journal of Cellular Physiology 214 (3): 796-809. IF 7.5 http://www.ncbi.nlm.nih.gov/pubmed/17849448
  4. Banerjee B, Sharma S, Hegde S, Hande MP 2008 Analysis of telomere damage by fluorescence in situ hybridisation on micronuclei in lymphocytes of breast cancer patients after radiotherapy. Breast Cancer Research and Treatment 107 (1):25-31. IF 4.453 http://dx.doi.org/17333339

2005-2008

  1. Li J, Tan J, Zhuang L, Banerjee B, Yang X, Chau JFL, Lee PL, Hande MP, Li B, Yu Q 2007 Ribosomal Protein S27-like a p53-inducible modulator of cell fate in response to genotoxic stress Cancer Research 67 (23): 11317-11326. IF 7.63 http://www.ncbi.nlm.nih.gov/pubmed/18056458
  2. Khaw AK, Silasudjana M Banerjee B, Suzuki M, Baskar R,  Hande MP† 2007 Inhibition of telomerase activity and human telomerase reverse transcriptase gene expression by histone deacetylase inhibitor in human brain cancer cells. Mutation Research 625 (1-2): 134-144. IF 4.353 http://www.ncbi.nlm.nih.gov/pubmed/18056458
  3. Banerjee B, Vadiraj HS, Ram A, Rao R, Jayapal M, Gopinath KS, Ramesh BS, Rao N, Kumar A, Raghuram N, Hegde S, Nagendra HR, Hande MP† 2007 Effects of an integrated yoga program in modulating psychological stress and radiation-induced genotoxic stress in breast cancer patients undergoing radiotherapy. Integrative Cancer Therapies, 6 (3): 242-250. IF (2.264 ) http://www.ncbi.nlm.nih.gov/pubmed/17761637
  4. Niida H, Katsuno Y, Banerjee B, Hande MP, Nakanishi M 2007 Specific role of Chk1 phosphorylation in cell survival and checkpoint activation. Molecular and Cellular Biology 27(7): 2572-2581. IF 6.411 http://www.ncbi.nlm.nih.gov/pubmed/17242188
  5. Birendranath Banerjee, Aik Kia Khaw, Pradeepa Hande and M. Prakash Hande  Inhibiting telomerase in cancer therapy: Prospects and challenges Genomic instability and cancer, 2010: ISBN: 978-81-308-0405-7