Dr. Mrutyunjay Suar, Director
Professor
Ph. D. University of Delhi 2003
M. Sc. Goa University 1999

Fax: (+91) 674 272 5732
Email : msuar@kiitbiotech.ac.in

Dr. Suar's group work on Salmonella Typhimurium (STm) and Salmonella Enteritidis (SEn) infection biology in Streptomycin pre-treated mouse model especially looking at identification of new virulence factors of SEn through comparative genome wide screening approach; development of recombinant and safe Salmonella derived mucosal vaccine candidates, which are even safe in immuno-compromised mouse models. Further translational work is under progress to develop enterocolitic vaccine against common gastro-intestinal pathogens such as VibrioSalmonellaE. coli and Shigella. Dr. Suar group also works on several projects like Characterization of efficient probiotics and study of their molecular basis of interaction with enteropathogenic microbes like SalmonellaEnteritidis; Structural and Biological characterization of virulence proteins in SalmonellaTyphimuriumand investigating the functional role of differential alanine racemase gene of Salmonella EnteritidisExploring bacterial LPS modification: Its interaction with host and role in virulence; Transcriptomics of Salmonella with emphasis on the small non coding RNA complement involved in the acid tolerance response (ATR) and their influence on virulence and Identification and characterization of putative virulence factors inVibrio parahaemolyticus; Characterization of emerging MDR (Enterobacter) E. coli strains causing extended neonatal sepsis; Characterization of Type IV Pilin and pilin encoding islands in Salmonella enetrica serovar Enteritidis (P121509): Origins and interactions with phages; Novel cloning and chromosomal integration techniques, phage remodeling and vaccine development, construction of a modular genetic ALU; Synthesis of different nanoparticles and understanding their implication in biological systems.

Post-Doctoral Training

  • Postdoctoral Fellow at Institute of Microbiology, ETH Zurich from Feb 2004-May 2007

Research Interest

We are interested in understanding the virulence of different Salmonella enterica serovars in a mouse model. Infection experiments with wild type and different mutant strains of different serovars are under investigation. Also started a genome based screening to find out new virulence or colonization factors in Salmonella enterica serovar Typhimurium and Enteritidis. Based on above studies and with more immunobiology studies, we are aiming to develop safe vaccine candidates not only for humans but also for other animals (cows) and birds (chickens) against enterocolitic pathogens.

  1. Understanding the molecular mechanism of Salmonella enterica serovar Enteritidis based enterocolitis in mouse model
  2. Development of a safe live recombinant Salmonella vaccine against enterocolitic diseases
  3. Development of early diagnostic kits for diseases like typhoid and diarrhea in rural health set-up

Awards/Honours

  • Recipient of G P Chatterjee memorial lecture award during 101st Indian Science Congress at University of Jammu, 2014.
  • Recipient of ASM Professorship award of 2012 and visited the lab of Prof. Jeff Miller (ASM President), UCLA in June 2013 for a month.
  • Selected as a future young technical leader of India & was invited as a speaker to Steinem rhein symposium, Switzerland, September 2010.
  • Nominated and invited to attend the Global Entrepreneurship Leadership Symposium (GELS), November, 16-23, 2009, UC-Berkeley
  • Invited as a speaker in Fourth Hanseatic India Colloquium Healthcare, Biotechnology and Pharmaceutical Sciences, 30th October 2009.
  • Young investigator Award from UBS Optimus foundation from 2008-2013
  • ETH Life sciences Zurich fellowships for 2 years 2004-2006
  • Visiting fellow to EAWAG, Dubendorf, Switzerland from Dec 2002-May 2003

Achievements

  • Dr. Suar is the Chief Executive of Technology Business Incubator at KIIT University (KIIT-TBI), which is promoting 23 start-ups in the field of ICT, Biotechnology and Engineering. This centre promotes innovation led enterprises establishment and job creation.
  • Dr. Suar founded a start up company Enoveo Biosolutions Pvt. Ltd working on several aspects of Bioengineering solutions and providing specialized services in the area of genomics and proteomics.
  • Dr. Suar also established the Sewati Sewa Sadan at a rural village K. Nuagan, Chikiti, District of Ganjam, Odisha. It has a 12 bed primary healthcare set-up with modern diagnostic facility including PCR, ELISA and other analyzers. One student is doing his PhD work in this set up in the area of public health. This centre promotes also science communication and capacity building as a part of outreach program.
  • Recipient of “G. P. Chatterjee Memorial Lecture award” for 2013-2014 from Indian Science Congress Association during Indian science Congress at Jammu.
  • Recipient of ASM Professorship award of 2012 and visited the lab of Prof. Jeff Miller (ASM President), UCLA in June 2013 for a month.
  • Selected as a future young technical leader of India & was invited as a speaker to Steinem rhein symposium, Switzerland, September 2010.
  • Nominated and invited to attend the Global Entrepreneurship Leadership Symposium (GELS), November, 16-23, 2009, UC-Berkeley
  • Invited as a speaker in Fourth Hanseatic India Colloquium Healthcare, Biotechnology and Pharmaceutical Sciences, 30th October 2009.
  • Young investigator Award from UBS Optimus foundation from 2008-2013
  • Postdoctoral Fellow at Institute of Microbiology, ETH Zurich from Feb 2004-May 2007
  • ETH Life sciences Zurich fellowships for 2 years 2004-2006
  • Visiting fellow to EAWAG, Dubendorf, Switzerland from Dec 2002-May 2003

Patents:

  • Balamurugn Periaswamy, Wolf Dietrich Hardt and Mrutyunjay Suar, Indian patent on "Live Attenuated Salmonella Vaccine". Application number 359/KOL/2012, filed on 30.03.2012.
  • Santosh Kar, Gobardhan Das and Mrutyunjay Suar, Indian patent on “A pharmaceutical Combination for treating Tuberculosis”. Application number 413/KOL/2013 filed on 15.04.2013

Selected Publications

Full List
  1. Vishwakarma V, Pati NB, Ray S, Das S, Suar M. 2014. TTSS2-deficient hha mutant of Salmonella Typhimurium exhibits significant systemic attenuation in immune-compromised hosts. Virulence. Feb 15;5(2):311-20. doi: 10.4161/viru.27605.
  2. Pati NB, Vishwakarma V, Periaswamy B, Hardt WD, and Suar M. 2013. Deletion of invH gene in Salmonella enterica serovar Typhimurium limits the secretion of SipA effector protein. Microbes & Infection Jan;15(1):66-73
  3. Singh Y, Kaul V, Mehra A, Chatterjee S, Tousif S, Dwivedi VP, Suar M, Kaer LV, Bishai WR, Das G. 2013. Mycobacterium tuberculosis controls miR-99b expression in infected murine dendritic cells to modulate host immunity. J Biol Chem. Feb 15;288(7):5056-61
  4. Vishwakarma V, Periaswamy B, Pati NB, Slack E, Hardt WD, Suar M. 2012. Novel phage element of Salmonella Enteritidis P125109 contributes to accelerated Type III secretion system-2 dependent early inflammation kinetics in mouse colitis model. Infect. Immun. 80 (9) 3236-46
  5. Stecher B, Chaffron S, Käppeli R, Hapfelmeier, S, Freedrich S, Weber T C, Kirundi J, Suar M, McCoy K, Mering C, Macpherson AJ, and Hardt WD. 2010. Like will to like: Abundances of closely related species as predictive values for the susceptibility to intestinal colonization by pathogenic and commensal bacteria, PLoS Pathogens, Jan;6(1):e1000711. Epub 2010 Jan 8

On-going Projects

R&D Projects

  • Identification and characterization of novel promoters of Salmonella enterica serovar Enteritidis contributing in virulence phenotype, Funded by DBT, Govt of India, 2013-2016
  • Characterization of sRNAs involved in the Acid Tolerance Response (ATR) in Salmonella and their influence on virulence, Funded by ICMR, Govt of India, 2014-2017
  • Isolation and Characterization of Benthic as well as Littoral Microbial Flora of Chilika Lake, Funded by ICZMP, World Bank, 2013-2016

Industrial Projects

  • Lab Testing of Purifier, field testing of water  & Urine samples and Genotoxicity testing, Funded by Hindustan Unilever Ltd (HUL)      in collaboration with London School of hygiene and Tropical Medicine (LSHTM), 2014-2015

Innovation Projects

  • Establishment of KIIT Technology Business Incubator promoting Technology enabled start-up culture, funded by DST, BIRAC-DBT, TDB, MSME & DIT, Govt of India.
  • Establishment of Rural Women Technology Park promoting rural innovation and entrepreneurship, Funded by DST, Govt of India, 2014-2017

Societal Projects

  • Early diagnosis of causative agents of diarrhea, malaria and typhoid for effective healthcare management: A pilot study in a rural            Health centre, Funded by DBT, Govt of India, 2012-2015
  • Development of water educators and ambassadors in rural set up, Funded by NCSTC, DST, Govt of India, 2014-2016

International Programs

  • Erasmus Mundus student and faculty exchange program with 10 European Universities, 2014-2016
  • Indo-US Joint Center on Nanostructure Genomics:  Designing Functionality of 2-Dimensional Nanostructures and  Nano-Bio Interfaces, Funded by IUSSTF, 2014-2016

Completed Projects

  • Identification of new virulence factors of Salmonella enterica serovar Enteritidis by genome wide mutant screening approach, Funded by DBT, Govt of India, 2010-2013
  • Mucosal Vaccine: Improved Life carrier vaccine strains--heterologous antigens, Funded by UBS Optmus Foundation, Zurich, 2008-2013

Collaborators

      International Collaborators

  1. Prof. Wolf Dietrich Hardt, Institute of Microbiology, ETH Zurich, Switzerland
  2. Prof. Trinad Chakraborty, University of Giessen, Germany
  3. Prof. Timothy Vogel, University of Lyon, France
  4. Prof. Cecilia Lundborg, Karolinska Institute, Sweden
  5. Prof. Thomas Classen, Emory University, USA

      National Collaborators

  1. Dr. Niyaz Ahmed, University of Hyderabad
  2. Dr. Neel S Bhavesh, ICGEB, New Delhi

Jugal K Das (Ph.D Scholar)
Topic: Characterization of efficient probiotics and study of their molecular basis of interaction with enteropathogenic microbe, Salmonella Enteritidis.
das.jugal.86@gmail.com

Sangeeta Jaiswal (Ph.D Scholar)
LPS modification in Salmonella Enteritidis conferring resistance to antimicrobials and its role in virulence
sangeetajswal04@gmail.com

Shilpa Ray (Ph.D Scholar)
Structural and Biological characterization of virulence proteins in S. Typhimurium and investigating the functional role of differential alanine racemase genes of S. Enteritidis.
shilpa.ray1988@gmail.com

Susmita Das (Ph.D Scholar)
Development of safe and recombinant mucosal vaccine against enterocolitic diseases
susmita_das@hotmail.com

Daniel Ryan (Ph.D Scholar)
Transcriptomics of Salmonella with emphasis on the small non coding RNA complement involved in the acid tolerance response (ATR) and their influence on virulence.
danielryan9287@gmail.com

Aryashree Arunima (Ph.D Scholar)
Identification and characterization of putative virulence factors in Vibrio parahaemolyticus
aarunima2@gmail.com

Suresh K Verma (Ph.D Scholar)
Synthesis of green nanoparticles and understanding their implication in biological systems
sureshverma22@gmail.com

Kunal Samantaray (JRF)
Novel cloning and chromosomal integration techniques, phage remodeling and construction of a modular genetic ALU
kunalcs90@gmail.com

Sushree S Sahoo (Project Fellow)
Characterization of Type IV Pilin and pilin encoding islands in Salmonella enetrica serovar Enteritidis (P121509): Origins and interactions with phages.
sushi.sahoo@gmail.com

Shantoshini Dash (Project Fellow)
Characterization of emerging MDR (Enterobacter) E. coli strains causing extended neonatal sepsis.
shantoshini@gmail.com

Bikash Ranjan Sahu
Research Scientist
View Profile
bikashsahu@gmail.com

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